Salmeterol : The Optimization of an Asthmatic Drug :: Medical Biology Asthma Medicine

Salmeterol The Optimization of an Asthmatic DrugAbstractAsthma can be found in so many people all across world. Asthma is not biasedsex, race, or country does not matter. Asthma affects a large percent of the globalpopulation. Becoming aware of this is the first base step. Now, utilize a drug in use,salmeterol, I want to perfect this drug to make it better by giving it divers(prenominal) analogs,which will give it different properties. Using the latest technology in the Chemistry Lab,Gaussview and Gaussian 03W aided me in creating models for these analogs andoptimizing them.3Imagine you are a cross country smuggler competing in the annual Mt. Sac CrossCountry Invitational. The finish line is just onward, and the crowd is going wild withexcitement. The top runner is slightly ahead of you, and you decide to sprint the last fiftyyards to the finish line, hopefully to attain first place. Nearing the finish line, yousuddenly claim trouble breathing, and your heartbeat becomes irre gular. You quickly lay down you are having an acute asthma attack and pull out your inhaler. With a deepbreath and a small puff, you feel better. However, the time it took to complete the swear out cost you, and you will have to settle with second place. Better luck next timeAsthma is a growing chronic condition in America and has taken quite a toll onAmericans. According to the American Academy of Allergy Asthma & Immunology (1),approximately twenty million Americans have asthma, half of which are specifically fromallergic asthma. With so many people with the condition, it is no surprise that in 2001, aquarter of all Emergency get on visits were caused by asthma. As a result, health costsfor asthma have soared and have hit ten billion dollars annually. Unfortunately, notevery person has been fitting to survive the effects of asthma, and approximately fivethousand deaths occur due to asthma yearly. Though the sole cause of asthma isunknown, there are several(prenominal) probable h ypotheses as to why one would attain asthma (7).As a result, asthma awareness must be spread. Not only does a large part of theAmerican population have this condition, but they also do not know how they got thecondition. This has led me to create a goal to optimize salmeterol, a drug used forasthma. However, many do not know what asthma is.4To fully grasp the concept of asthma, one must first analyze the system that itaffects the respiratory system, which controls the inhalation and exhalation of air.Following the pathway of air, it begins in the atmosphere and enters the body through